Ibuprofen and Asthma

What is The Correlation of Ibuprofen and Asthma

Rarely, papillary necrosis or interstitial fibrosis related with NSAIDs can cause kidney failure. Hepatic damage, alveoli is pulmonary eosinophilia, pancreatitis, eye changes, Stevens-Johnson and toxic epidermal necrolysis syndromes else rare side effects. An induction or exacerbation of colitis had been reported. Aseptic meningitis has been reported rarely with NSAIDs; patients with connective tissue disorders such as systemic lupus erythromatosus may be particularly vulnerable. “

There are many reports in the clinical literature ibuprofen-induced broncho-spasms (asthma attack), most especially in patients who have sensitivity to aspirin or other non-steroidal anti-inflammatory drugs. In extreme cases, such attacks could be fatal.

In regards with the widespread availability of ibuprofen in both the recipes and over-the-counter preparations, the number of adverse response reported were minor, but for patients with aspirin-sensitivity, risk of asthma attack increased significantly.

Some of studies have provided evidence for the direct effect of ibuprofen in the modulation of biochemical processes underlying the regulation of the airway and the appearance asthma attacks.

The UK National Formulary describing Ibuprofen and Asthma as follows:

Common: “Ibuprofen is a prop-ionic acid derivative with anti-inflammatory, analgesic and antipyretic has much less side effects than other NSAIDs (non-steroidal anti-inflammatory drugs) but anti-inflammatory properties are weaker.

Indications: “Painful and inflammation in rheumatic diseases (including juvenile arthritis) and other musculoskeletal problems; mild to moderate pain including dysmenorrheal, postoperative analgesia, fever and pain in children.”

Dosage 1.6 – 2.4 G per day is needed for rheumatoid arthritis, and this is not suitable for conditions in which inflammation prominent as acute gout. “

CSM warning (asthma): “Each degree of worsening of asthma may be related with the consumption of NSAIDs, either prescription or (in the case of ibuprofen, etc.) purchased over the counter.”

Contraindications: “NSAIDs are contraindicated in patients with a history of hypersensitivity to aspirin or other NSAIDs – including people with asthma, angioedema, urticaria or rhinitis”

Side-Effects: “The side effects of NSAIDs vary in severity and frequency of gastrointestinal discomfort, nausea, diarrhea, and sometimes bleeding or ulceration occur; dyspepsia can be minimized by taking medication with food or milk other side effects including hypersensitivity reactions (. . Especially rash, angioedema, and bronchospasm), headache, dizziness, vertigo, hearing disorders such as tinnitus, photosensitivity and hematuria. Blood disorders also happen fluid retention can occur (rarely accelerate congestive heart failure in elderly patients) .. Kidney failure may be provoked with NSAIDs, especially in patients with pre-existing kidney disorders.

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